☞ Specification & Ordering Information
 

■ Product Name : Recombinant Human TERT Protein, His/GST-tagged

■ Cat.No. : TERT-438H

■ Product Overview : Recombinant Human TERT(Arg787~Arg1084) fused with His/GST tag at N-terminal was expressed in E. coli.

■ Description : Telomerase is a ribonucleoprotein polymerase that maintains telomere ends by addition of the telomere repeat TTAGGG. The enzyme consists of a protein component with reverse transcriptase activity, encoded by this gene, and an RNA component which serves as a template for the telomere repeat. Telomerase expression plays a role in cellular senescence, as it is normally repressed in postnatal somatic cells resulting in progressive shortening of telomeres. Deregulation of telomerase expression in somatic cells may be involved in oncogenesis. Studies in mouse suggest that telomerase also participates in chromosomal repair, since de novo synthesis of telomere repeats may occur at double-stranded breaks. Alternatively spliced variants encoding different isoforms of telomerase reverse transcriptase have been identified; the full-length sequence of some variants has not been determined. Alternative splicing at this locus is thought to be one mechanism of regulation of telomerase activity.

■ Source : E. coli

■ Species : Human

■ Tag : His&GST

■ Form : 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01%skl, 5% Trehalose and Proclin300.

■ Molecular Mass : 65.8kDa
Protein length : Arg787~Arg1084

■ Endotoxin : <1.0EU per 1ug (determined by the LAL method)

■ Purity : > 97%

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